Research Interests and Directions
1. Identification of disease-related T cell phenotypes and functions
2. Screening of disease-related T cell antigen epitopes to elucidate mechanisms of T cell-mediated diseases
3. Antigen epitope and TCR-based disease therapies, such as peptide vaccines, mRNA vaccines, and TCR-T
- Recipient of a National Talent Program (2021)
- Graduated with a bachelor's degree from Central South University in 2005, a master's from the Chengdu Institute of Biology, CAS in 2008, and a PhD from the University of Science and Technology of China in 2012.
- Conducted postdoctoral research at USTC (2012-2015) and University Hospital Zurich (2017-2021).
- Joined the School of Life Sciences and Medicine, USTC in October 2021.
- Research focuses on T cell antigen epitope screening, activation, peripheral maintenance, and directed migration.
- Published as first or co-corresponding author in journals such as Cell, J Exp Med, Nat Commun, J Immunol, J Autoimmun, and Front Immunol.
Representative Papers
Wang J, Jelcic I, Mühlenbruch L, Haunerdinger V, Toussaint N, Zhao Y, Cruciani C, Faigle W, Naghavian R, Foege M, Binder T, Eiermann T, Opitz L, Fuentes-Font L, Reynolds R, Kwok W, Nguyen J, Lee J, Lutterotti A, Münz C, Rammensee H, Hauri-Hohl M, Sospedra M, Stevanovic S, and Martin R (2020). HLA-DR15 Molecules Jointly Shape an Autoreactive T Cell Repertoire in Multiple Sclerosis. Cell 183(5):1264-1281 e20.
Jelcic I*, Al Nimer F*, Wang J, Lentsch V, Planas R, Jelcic I, Madjovski A, Ruhrmann S, Faigle W, Frauenknecht K, Pinilla C, Santos R, Hammer C, Ortiz Y, Opitz L, Grönlund H, Rogler G, Boyman O, Reynolds R, Lutterotti A, Khademi M, Olsson T, Piehl F, Sospedra M, and Martin R (2018). Memory B Cells Activate Brain-Homing, Autoreactive CD4(+) T Cells in Multiple Sclerosis. Cell 175, 85-100 e123. (*Co-first author)
Huang C, Wang J*, Zheng X, Chen Y, Wei H, Sun R, and Tian Z* (2018). Activation of TLR Signaling in Sensitization-Recruited Inflammatory Monocytes Attenuates OVA-Induced Allergic Asthma. Front Immunol 9, 2591. (*Co-corresponding author)
Huang C, Wang J*, Zheng X, Chen Y, Zhou R, Wei H, Sun R, and Tian Z* (2018). Commensal bacteria aggravate allergic asthma via NLRP3/IL-1beta signaling in post-weaning mice. J Autoimmun 93, 104-113. (*Co-corresponding author)
Wang J*, Li F*, Wei H, Lian Z, Sun R, and Tian Z (2014). Respiratory influenza virus infection induces intestinal immune injury via microbiota-mediated Th17 cell-dependent inflammation. J Exp Med 211, 2397-2410. (*Co-first author)
Wang J, Li F, Sun R, Gao X, Wei H, and Tian Z (2014). Klebsiella pneumoniae alleviates influenza-induced acute lung injury via limiting NK cell expansion. J Immunol 193, 1133-1141.
Wang J*, Li F*, Sun R, Gao X, Wei H, Li L, and Tian Z (2013). Bacterial colonization dampens influenza-mediated acute lung injury via induction of M2 alveolar macrophages. Nat Commun 4, 2106. (*Co-first author)
Recruitment
1. Recruiting postdoctoral researchers with backgrounds in molecular biology, immunology, or bioinformatics
2. Welcoming students interested in cellular immunology for master's, PhD degrees, and undergraduate internships
Contact Information
Email: ustcwj@ustc.tsg211.com