Ph.D. Supervisor, Researcher and Physician at the Reproductive Center of the First Affiliated Hospital of the University of Science and Technology of China. Recognized as a key young technical talent in the hospital's inaugural cohort and a candidate for provincial academic and technical leadership.
Contact Information
E-mail: wuliminmail@126.com
Phone: 0551-62283402-808
Education and Work Experience
- 1994-1999: Bachelor's Degree in Traditional Chinese Medicine, Anhui University of Traditional Chinese Medicine
- 1999-2002: Master's Degree in Traditional Chinese Internal Medicine, Anhui University of Traditional Chinese Medicine
- 2012-2015: Master's Degree in Reproductive Medicine and Prenatal Diagnosis, Anhui Medical University
- 2003-2007: Ph.D. in Biology, School of Life Sciences, University of Science and Technology of China
- 2008-2010: Postdoctoral Fellow in Reproductive Biology and Molecular Genetics, University of Science and Technology of China
- 2014-2015: Visiting Scholar, City of Hope National Medical Center & Beckman Research Institute, USA
- 2007-Present: Reproductive Center & Prenatal Diagnosis Center, Anhui Provincial Hospital, specializing in Assisted Reproductive Medicine and Prenatal Diagnosis
Academic Achievements and Impact
Dr. Wu has dedicated over 20 years to teaching and research in assisted reproductive technology, infertility, eugenics, recurrent miscarriage, and the integration of traditional Chinese and Western medicine in obstetrics and gynecology. She has supervised 16 master's students. Her primary research findings have been published in journals such as PNAS, Neuropsychopharmacology, Human Reproduction, and Biology of Reproduction, with over 60 papers and approximately 400 citations. Dr. Wu has led three projects funded by the National Natural Science Foundation of China (NSFC) and one provincial key technology project. She has received a second prize and two third prizes for provincial scientific and technological progress, as well as two second prizes for provincial traditional Chinese medicine scientific and technological achievements.
Ongoing Projects (Principal Investigator Only)
- Project Name: Homozygous Frameshift Mutation (c.834delC) in the Calcium Channel Gene CATSPER2 Leading to Fertilization Disorder and Male Infertility
- Source: [Funding Source]
- Total Funding: 550,000 RMB
- Duration: 2020-01 to 2023-12
Primary Research Areas (Graduate Programs) and Content
Biology:
1. Molecular genetic mechanisms of abnormal human spermatogenesis and oocyte maturation disorders.
2. Molecular mechanisms of repeated implantation failure and recurrent miscarriage, and the mechanisms of integrated traditional Chinese and Western medicine treatments.
3. Effects and mechanisms of psychosomatic stress on follicular development and embryo implantation.
Clinical Medicine:
Obstetrics and Gynecology:
1. Molecular genetic mechanisms of abnormal human spermatogenesis and oocyte maturation disorders.
2. Molecular mechanisms of repeated implantation failure and recurrent miscarriage, and the mechanisms of integrated traditional Chinese and Western medicine treatments.
3. Effects and mechanisms of psychosomatic stress on follicular development and embryo implantation.
Representative Papers (Last 5 Years, First or Corresponding Author)
1. Yan Sun#, Jing Yuan#, Limin Wu(吴丽敏)# , Min Li, Xiaoli Cui, Chengbin Yan, Lique Du, Liangwei Mao, Jianfen Man, Wei Li, Karsten Kristiansen, Xuan Wu, Weijun Pan, Yun Yang. Panel-based NGS reveals disease causing mutations in hearing loss patients using BGISEQ-500 platform, Medicine, 2019, 98（12）：e14860
2. Wu LM (吴丽敏), Zheng MC, Bao MM, Tong XH, Liu YS, Han H. Pregnancy outcome of recurrent spontaneous abortion in Wilson’s disease after decoppering therapy. Clinical and experimental obstetrics & gynecology, 2019,46(4): 626-629
3. Han H, Wu LM (吴丽敏)*, Han MX, Yang WM, Wang YX, Fang ZH. Diabetes impairs spatial learning and memory and hippocampal neurogenesis via bdnf in rats with transient global ischemia.Brain Research Bulletin, 2016, 124, 269-277.
4. Wu LM (吴丽敏), Li NN, Zhang MF, Xue SL, Cassady K., Lin Q, Riggs A., Zeng D. MHC-mismatched mixed chimerism augments thymic regulatory T cell production and prevents relapse of EAE[J], Proceedings of the National Academy of Sciences, 2015，112(52):15994-15999
5. 方群英,吴丽敏*,童先宏. 常规IVF受精失败相关危险因素的Logistic回归分析. 现代妇产科进展,2020,29(3):199-202,207.
6. 方群英, 吴丽敏*, 孙秀英, 刘芬, 方朝晖.不同中医证候多囊卵巢综合征不孕患者促排加指导同房临床特征和妊娠结局比较. 中华中医药学刊, 2019，37(11), 104-108.
7. 孙秀英, 吴丽敏*, 刘芬, 梁慧. 卵巢储备功能下降患者不同中医证候体外受精-胚胎移植妊娠结局比较.中华中医药杂志,2019,34(8):3450-3454
8. 方群英，吴丽敏*，孙秀英，方朝晖.多囊卵巢综合征不孕患者中医证候分布规律研究. 时珍国医国药，2018,29(12): 3067-3070页
9. 刘芬，吴丽敏*，韩辉，孙秀英，方群英，梁慧，詹桃桃，栾红兵，童先宏. 中西医结合周期治疗对卵泡发育不良不孕症妊娠结局的影响. 中华中医药学刊, 2018,36(11):2678-2681
10. 吴丽敏，鲍蔓蔓，童先宏，金仁桃，许波, 卢芳汀，刘雨生. 早期补救卵胞浆内单精子注射妊娠结局及新生儿出生结局评估. 实用妇产科杂志, 2018, 34(10):782-786
11. 韩辉，郑明翠，宋书婷,吴丽敏*.肝豆状核变性中医证型与ATP7B基因突变的相关性研究.中国中西医结合杂志,2018,38(7):799-804
12. 韩辉, 郑明翠, 吴丽敏*,许金波. 肝豆灵对肝豆状核变性TX小鼠ERK信号通路及空间学习记忆的影响. 时珍国医国药, 2018，29(3)：553-555
13. 庞丽娥,乔宗惠,吴丽敏*,刘瑞华，童先宏，刘雨生.不同年龄卵巢储备功能下降患者体外受精-胚胎移植临床结局比较,生殖与避孕,2016;36(11):945-949