、
Dr. Shu Zhu
Professor and Dean, Division of Life Science and Medicine, University of Science and Technology of China.
Dr. Zhu received his Bachelor degree at University of Science and Technology of China, and completed his PhD at Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences. He has been trained as a postdoc fellow in Richard Flavell’s lab at Immunobiology department, Yale University. He became a professor at University of Science and Technology of China since 2017.
His lab is currently using various mouse models and molecular/cellular/omics techniques to study intestinal immune responses toward environmental cues including microbes and food. They demonstrated how dsRNA from enteric viruses (norovirus, rotavirus, and commensal viruses) are recognized by intestinal epithelial cells-specific Nod-like recpetors-Nlrp6 and Nlrp9, and activate inflammasome and interferon (PNAS, 2024; Cell, 2021; Nature, 2017a; Science, 2015); and also sensed by DC-expressed Rig-I to sustain the expansion of intraepithelial lymphocytes (Nature Immunology, 2019). His lab recently elucidated that the dietary-antigen-dependent cleavage of Gasdermin D maintains food toleranceirrespective of pyroptosis (Cell, 2023).
His lab has also investigated the potential immune mechanisms that contribute to microbiota dysbiosis (Cell Research, 2022; PNAS, 2021), and role of microbiota dysbiosis (elevated Clostridium scindens, Peptostreptococcus anaerobius, or Enterococcus faecalis and these bacteria produced metabolites DCA, IDA, or Tyramine) in colorectal cancer or IBD development (Immunity, 2024; Nature Cell Biology, 2024; Cell Host Microbe, 2024); They also developed strategies (glucosylated nanoparticle encapsulated antibiotics or vitamin B5 supplementation) to intervene microbiota dysbiosis and associated diseases such as IBD (Nature Biomedical Engineering, 2022; Cell Reports, 2022).
Dr. Zhu received a series of national talent scholarships, as well as career stage awards including
Guo Moruo Scholarship, RayWu prize, Helen Hay Whitney/HHMI Fellowship, MIT Technology Review 35 Innovators Under 35 China, and Qiushi Award, etc. He is also an amateur painter and an amateur soccer player.
Lab webpage：http://zhulab.ustc.tsg211.com/
E-mail：zhushu@ustc.tsg211.com
Tel：0551-63600317
OCRID ID: 0000-0002-8163-0869
Publications：(*First or co-first author，#Corresponding or Co-corresponding author)
2024
74. Cong J*, Liu P*, Han Z*, Ying W, Li C, Yang J, Song X, Dai L, Sun L, Kasper D, Pan W#, Zhu S#. Bile acids modified by the microbiota suppress gut anti-tumor immune responses. Immunity. 2024 Mar 6:S1074-7613(24)00090-6. doi: 10.1016/j.immuni.2024.02.014. (IF=43.5)
Preview in:
Immunity.doi: 10.1016/j.immuni.2024.03.006. Hostile bile limits anti-cancer immunity.
73. Eran Elinav, Suzanne Devkota, Marlies Meisel, Shu Zhu, Hiutung Chu, Haiwei Chen, Jens Puschhof, Florencia McAllister, Randall Jeffrey Platt, Kenya Honda, Microbes and metabolites in immunity, Immunity. doi.org/10.1016/j.immuni.2024.08.011 (Inivited Voice: Shu Zhu. Food, microorganisms, and the immune system)
72. Li C, Zhang P, Xie Y, Wang S, Guo M, Wei X, Zhang K, Cao D, Zhou R, Wang S, Song X#, Zhu S#, Pan W#. Enterococcus-derived tyramine hijacks α2A-adrenergic receptor in intestinal stem cells to exacerbate colitis. Cell Host Microbe. 2024 May 21:S1931-3128(24)00140-9. doi: 10.1016/j.chom.2024.04.020. (IF=30.1)
71. Zhu S#, Pan W#. Microbial metabolite steers intestinal stem cell fate under stress. Cell Stem Cell. doi.org/10.1016/j.stem.2024.04.006. (IF=23.9)
70. J Wu*, W Zeng*, H Xie*, M Cao, Y Xie, Z Luo, H Xu, W Huang, S Zhu#, R Mao#, Z He#, P Lan#. Microbiota-induced alteration of kynurenine metabolism in macrophages drive the formation of creeping fat in Crohn’s disease. Cell Host Microbe. Accepted. (IF=30.1)
69. Ren X, Liu Q, Zhou P, Zhou T, Wang D, Mei Q, Flavell RA, Liu Z#, Li M#, Pan W#, Zhu S#. DHX9 maintains epithelial homeostasis by restraining R-loop-mediated genomic instability in intestinal stem cells. Nature Communications. 2024 Apr 9;15(1):3080. doi: 10.1038/s41467-024-47235-2. (IF=16.6)
68. Hu J*, He K*, Yang Y*, Huang C, Dou Y, Wang H, Zhang G, Wang J, Niu C, Bi G, Zhang L#, Zhu S#. Amino-acid formula induces microbiota dysbiosis and contributes to depressive-like behavior. Cell Reports. 2024 Feb 26;43(3):113817. doi: 10.1016/j.celrep.2024.113817. (IF=10.0)
67. Li R*, Zan Y*, Wang D, Chen X, Wang A, Tan H, Zhang G, Ding S, Shen C#, Wu H#, Zhu S#. A mouse model to distinguish NLRP6-mediated inflammasome-dependent and independent functions. PNAS. 2024 Feb 6;121(6):e2321419121. doi: 10.1073/pnas.2321419121. (IF=11.1)
66. W Cui, M Guo, D Liu, Y Zhang, J Cong, Z Han, Y Yang, J Liu, C Liang, S Shi, P Xiao, C Yang, H Huang, X Fu, Y Xu, L Du, C Yin, Y Zhang, J Sun, R Chai#, W Gu#, S Zhu#, B Chu#. Gut microbial metabolite facilitates colorectal cancer development via ferroptosis inhibition. Nature Cell Biology. 26, 124–137 (2024). (IF=28.2)
2023
65. K He*, T Wan*, D Wang*, J Hu*, T Zhou, W Tao, Z Wei, Q Lu, R Zhou, Z Tian, R Flavell#, and S Zhu#. Gasdermin D licenses MHCII induction to maintain food tolerance in small intestine. Cell. 2023 Jun 9;S0092-8674(23)00577-9. doi: 10.1016/j.cell.2023.05.027. (IF=66.9)
Comment in:
Trends in Immunology. 2023 Aug;44(8):571-573. doi: 10.1016/j.it.2023.06.006. Chopped! Newfound GSDMD cleavage facilitates tolerance to food allergens.
Cell Research. 2023 Dec;33(12):896-897. doi: 10.1038/s41422-023-00856-6. Cleaving an epithelial path to food tolerance.
Gastroenterology. doi:10.1053/j.gastro.2023.08.024. Tolerance to Dietary Antigens in the Upper Intestine Through Chopping of Gasdermin D.
Allergy. doi: 10.1111/all.16076. Insights in intestinal immune tolerance: The role of the cleavage form of gasdermin D.
64. T Wan*, Y Wang*, K He*, S Zhu#. Microbial sensing in the intestine. Protein & Cell, pwad028, 2023. doi.org/10.1093/procel/pwad028. (IF=15.3)
63. H Ma*, T Hu*, W Tao, J Tong, Z Han, D Herndler-Brandstetter, Z Wei, X Xu, K Zhang, R Liu, T Zhou, Q Liu, J Cho, HB Li#, H Huang#, R Flavell#, and Zhu S#. A lncRNA from an inflammatory bowel disease risk locus maintains intestinal host-commensal homeostasis. Cell Research. 2023, doi.org/10.1038/s41422-023-00790-7. (IF=46.3)
62. X Ren, D Wang, G Zhang, T Zhou, Z Wei, Y Yang, Y Zheng, X Lei, W Tao, A Wang, M Li#, R Flavell#, Zhu S#. Nucleic DHX9 Cooperates with STAT1 to Transcribe Interferon-Stimulated Genes. Science Advance.2023 Feb 3;9(5):eadd5005. DOI: 10.1126/sciadv.add5005 (IF=14.1)
61. X Wang*, C Chen*, H Sun*, K Mao*, J Yao, W Zhang, M Zhan, H-B Li, Z Zhang#, S Zhu#, L Lu#. m6A mRNA modification potentiates Th17 functions to inflame autoimmunity. Sci. China Life Sci. (2023). https://doi.org/10.1007/s11427-022-2323-4. (IF=10.4)
60. Liu Z, Liu R, Gao H, Jung S, Gao X, Sun R, Liu X, Kim Y, Lee HS, Kawai Y, Nagasaki M, Umeno J, Tokunaga K, Kinouchi Y, Masamune A, Shi W, Shen C, Guo Z, Yuan K; FinnGen; International Inflammatory Bowel Disease Genetics Consortium; Chinese Inflammatory Bowel Disease Genetics Consortium; Zhu S, Li D, Liu J, Ge T, Cho J, Daly MJ, McGovern DPB, Ye BD, Song K, Kakuta Y, Li M, Huang H. Genetic architecture of the inflammatory bowel diseases across East Asian and European ancestries. Nature Genetics. 2023 May;55(5):796-806. doi: 10.1038/s41588-023-01384-0. Epub 2023 May 8. PMID: 37156999; PMCID: PMC10290755. (IF=30.8)
59. Wang J, Zhao D, Lei Z, P Ge, Z Lu, Q Chai, Y Zhang, L Qiang, Y Yu, X Zhang, B Li, S Zhu, L Zhang#, C Liu#. TRIM27 maintains gut homeostasis by promoting intestinal stem cell self-renewal. Cell Mol Immunol 20, 158–174 (2023). https://doi.org/10.1038/s41423-022-00963-1. (IF=24.1)
2022
58. Zhang G*, Wang Q*, Tao W*, Jiang W, Elinav E, Wang Y#, Zhu S#. Glucosylated nanoparticles for the oral delivery of antibiotics to the proximal small intestine protect mice from gut dysbiosis. Nature Biomedical Engineering. 2022 Jul;6(7):867-881. doi: 10.1038/s41551-022-00903-4. (IF=29.2)
57. Chen C*, W Zhang*, T Zhou, Q Liu, C Han, Z Huang, S Chen, Q Mei, C Zhang, K Zhang, H Ma, R Zhou, W Jiang, Wen Pan, Zhu S#. Vitamin B5 rewires Th17 cell metabolism via impeding PKM2 nuclear translocation. Cell Reports. 2022 Nov 29;41(9):111741. doi: 10.1016/j.celrep.2022.111741. (IF=10.0)
56.A Wang, W Tao, J Tong, J Gao, J Wang, G Hou, C Qian, G Zhang,R Li, D Wang, X Ren, K Zhang, S Ding, R Flavell, HB Li, W Pan#, S Zhu#.m6A modifications regulate intestinal immunity and rotavirus infection. Elife.2022;11:e73628 DOI: https://doi.org/10.7554/eLife.73628 (IF=8.1)
55. Y Chen, X Wang, X Hao, B Li, W Tao, S Zhu, K Qu, H Wei, R Sun, H Peng, Z Tian. Ly49E separates liver ILC1s into embryo-derived and postnatal subsets with different functions. J Exp Med. 2022, 219(5): e20211805. (IF=17.58)
2021
54. Shen C*, Li R*, Negro R, Cheng J, Vora SM, Fu TM, Wang A, He K, Andreeva L, Gao P, Tian Z, Flavell RA, Zhu S#, Wu H#. Phase separation drives RNA virus-induced activation of the NLRP6 inflammasome. Cell. 2021 Oct 14:S0092-8674(21)01115-6. doi:10.1016/j.cell.2021.09.032. (IF=41.6)
Comment in:
Cell Research. doi: 10.1038/s41422-021-00594-7. It’s just a phase: NLRP6 phase separations drive signaling.
53. M Guo*, W Tao*, R Flavell#, and S Zhu#. Potential intestinal infection and fecal–oral transmission of SARS-CoV-2. Nature Reviews Gastroenterology & Hepatology. 10.1038/s41575-021-00416-6 (IF=46.8)
52. Y Wang*, K He*, B Sheng*, X Lei, W Tao, X Zhu, Z Wei, R Fu, A Wang, S Bai, Z Zhang, N Hong, C Ye, Y Tian, J Wang, K Zhang, H Yang, L Li#, H Li#, R Flavell#, S Zhu#. The RNA helicase Dhx15 mediates Wnt-induced anti-microbial protein expression in Paneth cells. PNAS. 2021, 10.1073/pnas.2017432118 (IF=11.2)
51. Z Zhang*, G Zhang*, M Guo*, W Tao*, X Liu, H Wei, T Jin#, Y Zhang#, S Zhu#. The Potential Role of an Aberrant Mucosal Immune Response to SARS-CoV-2 in the Pathogenesis of IgA Nephropathy. Pathogens. 2021, 10(7), 881. doi: 10.3390/pathogens10070881(IF=3.5)
50. J Tong, X Wang, Y Liu, X Ren, A Wang, Z Chen, J Yao, K Mao, T Liu, F Meng, W Pan, Q Zou, J Liu, Y Zhou, Q Xia#, R Flavell#, S Zhu#, HB Li#. Pooled CRISPR Screening Identifies m6A as a Positive Regulator of Macrophage Activation. Science Advance. 10.1126/sciadv.abd4742 (IF=14.1)
49. Y Chen, S Zhao, J Hu, C Han, X Lv, G Wang, S Wang, P Bo, J Zhang, W Wu, W Gui, Q Tang#, Q Liu#, S Zhu#, F Yu#. Increased accumulation of α-Synuclein in inflamed appendix of Parkinson’s disease patients. Movement Disorders. 2021 Apr 20. doi: 10.1002/mds.28553 (IF=10.3)
48. X Zheng, L Liu, G Meng, S Zhu, R Zhou#, W Jiang#.IL-18 maintains the homeostasis of mucosal immune system via inflammasome-independent but microbiota-dependent manner. Science Bulletin. Doi: 10.1016/j.scib.2021.01.025 (IF=11.8)
47. Song H, Song J, Cheng M, Zheng M, Wang T, Tian S, Flavell RA, Zhu S, Li HB, Ding C, Wei H, Sun R, Peng H, Tian Z. METTL3-mediated m6A RNA methylation promotes the anti-tumor immunity of natural killer cells. Nat Commun. 2021 Sep 17;12(1):5522. doi: 10.1038/s41467-021-25803-0. (IF=14.9)
46. G Xu, C Liu, S Zhou, Q Li, Y Feng, P Sun, H Feng, Y Gao, J Zhu, X Luo, Q Zhan, S Liu, S Zhu, H Deng, D Li, P Gao. Viral tegument proteins restrict cGAS-DNA phase separation to mediate immune evasion. Molecular Cell. doi.org/10.1016/j.molcel.2021.05.002 (IF=18.0)
45. H Han, Y Cao, C Feng, Y Zheng, S Zhu, C Shang, C Yuan, G Zong. Association of a Healthy Lifestyle with All-Cause and Cause-Specific Mortality Among Individuals with Type 2 Diabetes: A Prospective Study in UK Biobank Short Running. Diabetes Care. doi.org/10.2337/dc21-1512 (IF=19.1)
2020
44. W Tao*, X Wang*, G Zhang*, M Guo, H Ma, D Zhao, L Liu, K Zhang, J Weng, Y Wang, X Ma#, T Jin# and S Zhu#. Re-detectable positive SARS-CoV-2 RNA tests in patients who recovered from COVID-19 with intestinal infection.Protein & Cell. 10.1007/s13238-020-00778-8 (IF=10.2)
43. R Li, S Zhu#. 2019. NLRP6 Inflammasome. Mol Aspect Med. 2020 Dec;76:100859. doi.org/10.1016/j.mam.2020.100859 (IF=9.6)
42. W Tao*, G Zhang*, X Wang*, X Ma, T Jin, L Liu#, J Weng#, and S Zhu#. Analysis of the intestinal microbiota in COVID-19 patients and its correlation with the inflammatory factor IL-18. Medicine in Microecology. 10.1016/j.medmic.2020.100023
41. W Wen*, G Zhang*, S Luo*, Z Bai, W Tao, M Guo, S Jia, W Liu, K Zhang, J Weng#, S Zhu#. Next-generation sequencing revealed influenza and Chlamydia infection in recurrent pneumonia in a recovered COVID-19 patient. Precision Clinical Medicine. 10.1093/pcmedi/pbaa033
40. L Yang*, T Geng*, G Yang*, J Ma, L Wang, H Ketkhar, D Yang, T Lin, J Hwang, S Zhu, Y Wang, J Dai, F You, G Cheng, A Vella, R Flavell#, E Fikrig#, P Wang#. Macrophage scavenger receptor 1 controls Chikungunya virus 2 infection through autophagy in mice. Communications Biology. 3, 556. https://doi.org/10.1038/s42003-020-01285-6 (IF=4.2)
2019
39. L Liu*, T Gong*, W Tao*, B Lin, C Li, X Zheng, S Zhu#, W Jiang#, R Zhou#. 2019. Commensal viruses maintain the homeostasis of intestinal intraepithelial lymphocytes via non-canonical RIG-I signaling. Nat Immunol.10.1038/s41590-019-0513-z. (IF=21)
Comment in:
Nature Reviews immunology, 2019 Dec;19(12):721. Commensal viruses contribute to gut health.
38. H Ma*, W Tao*, and S Zhu#. 2019. T Lymphocytes in Intestinal Mucosa: Defense and Tolerance. Cell Mol Immunol. (2019) 16:216–224. (Invited review) (IF=9)
37. A Wang and S Zhu#. 2019. Gut Viruses Firm the “Great Wall”. Precision Clinical Medicine.doi.org/10.1093/pcmedi/pbz027.
36. W Zhang and S Zhu#. 2019. Gut metabolites: make orphans adopted. Precision Clinical Medicine.doi:10.1093/pcmedi/pbz012.
35. A Wang*, G Zhang*, W Tao*, S Zhu#. 2019. The immune response towards enteric virus in inflammatory bowel disease. 2019. Chin J Inflamm Bowel Dis. January 2019, Vol.3, No.1 (Invited review)
34. W Tao, S Zhu#. 2019. Gut virome in health and disease. Journal of Biology, 2019, 36(6): 1-. (Invited review)
33. J Wang, MF. Sanmamed, I Datar, T Su, L Ji, J Sun, L Chen, Y Chen, G Zhu, L Zheng, T Zhou, T Badri, S Yao, S Zhu, A Boto, M Sznol, I Melero, DA. Vignali, K Schalper and L Chen#. 2018. Fibrinogen-like protein 1 is a major ligand of LAG-3 for T-cell suppression and the evasion of tumor immunity. Cell. 176, 1–14.doi:org/10.1016/j.cell.2018.11.010. (IF=32)
2018
32. S Ding, S Zhu, L Ren, N Feng, X Ge, B Li, RA Flavell, HB Greenberg#. 2018. Rotavirus VP3 targets MAVS for degradation to inhibit type III interferon expression in intestinal epithelial cells. Elife. 2018 Nov 21;7. pii: e39494. doi: 10.7554/eLife.39494. (IF=8)
31. L Wu, J Cao, WL Cai, SM Lang, JR Horton, DJ Jansen, ZZ Liu, JF Chen, M Zhang, BT Mott, K Pohida, G Rai, SC Kales, MJ Henderson, X Hu, A Jadhav, DJ Maloney, A Simeonov, S Zhu, A Iwasaki, MD Hall, X Cheng, GS. Shadel, Q Yan#. 2018. KDM5 histone demethylases repress immune response via suppression of STING. Plos Biology. 2018 Aug 6;16(8):e2006134. doi: 10.1371/journal.pbio.2006134. (IF=9)
30. J Tong, G Cao, T Zhang, E Sefik, M Amezcua Vesely, J Broughton, S Zhu, H Li, B Li, Lei Chen, H Chang, B Su, R Flavell# & HB Li#. 2018. m6A mRNA methylation sustains Treg suppressive functions. Cell Research. doi:10.1038/cr.2018.7 (IF=15)
2017
29. Zhu S*, Ding S*, Wang P, Wang G, Lei X, Palm N, Pan W, Zheng Y, Feng N, Lu J, Shan L, Abraham C, Fikrig E, Greenberg H#, Flavell R#. Nlrp9b recognizes and restricts rotavirus infection in intestinal epithelial cells. 2017. Nature. doi:10.1038/nature22967. (IF=42)
Comment in:
Nature. doi:10.1038/nature23090; Gut sensor halts viral attack
Nat Rev Gastroenterol Hepatol. doi: 10.1038/nrgastro.2017.94. Rotavirus: Inflammasome modulates rotavirus infection;
Cell Research. doi: 10.1038/cr.2017.93, NLRP9b: a novel RNA-sensing inflammasome complex.
28. Li, H.*, J. Tong*, S. Zhu*, P. Batista, J.Zhao, W. Bailis, Y. Yang, G. Wang, Y. Chen, Y. Kluger, Howard Y. Chang, Zhinan Yin#, Richard A. Flavell#. 2017. m6A mRNA methylation controls T cell homeostasis by targeting IL-7/STAT5/SOCS pathway. Nature. doi:10.1038/nature23450. (IF=42)
27. Pan W, Zhu S, K Qu, K Meeth, J Cheng, K He, H Ma, Y Liao, X Wen, C Roden, Z Tobiasova, Z Wei, J Zhao, J Liu, J Zheng, B Guo, M Bosenberg, R Flavell, J Lu#. 2017. Tet2 sustains the immunosuppressive function of myeloid cells and promotes melanoma growth. Immunity. 2017, doi: 10.1016/j.immuni.2017.07.020. (IF=24)
26. Yu H, Borsotti C, Schickel JN, Zhu S, Strowig T, Eynon EE, Frleta D, Gurer C, Murphy AJ, Yancopoulos GD, Meffre E, Manz MG, Flavell RA#. 2017. A novel humanized mouse model with significant improvement of class- switched, antigen-specific antibody production. Blood. doi: 10.1182/blood-2016-04-709584. (IF=12)
25. H Yu, N Gagliani, H Ishigame, S Huber, S Zhu, E Esplugues, K Herold, L Wen, R Flavell#. 2017. Intestinal type 1 regulatory T cells migrate to periphery to suppress diabetogenic T cells and prevent diabetes development. Proceedings of the National Academy of Sciences, doi: 10.1073/pnas.1705599114. (IF=10)
2016
24. Hu B, Jin C, Li HB, Tong J, Ouyang X, Cetinbas NM, Zhu S, Strowig T, Lam FC, Zhao C, Henao-Mejia J, Yilmaz O, Fitzgerald KA, Eisenbarth SC, Elinav E, Flavell RA#. 2016. The DNA Sensing Aim2 Inflammasome Controls Radiation Induced Cell death and Tissue Injury. Science. 2016 Nov 11;354(6313):765-768. (IF=41)
23. Shu Zhu, Geng Wang, Xuqiu Lei, Richard A. Flavell#. 2016. Mex3B, a coreceptor to present dsRNA to TLR3. Cell Research. 26(4):391-2. doi: 10.1038/cr.2016.29. (IF=15)
22. Cheng J, Roden CA, Pan W, Zhu S, Baccei A, Pan X, Jiang T, Kluger Y, Weissman SM, Guo S, Flavell RA, Ding Y, Lu J#. 2016. A Molecular Chipper Technology for CRISPR sgRNA Library Generation and Functional Mapping of Noncoding Regions. Nature Communication. 7:11178. doi: 10.1038/ncomms11178. (IF=12)
2015
21. Wang P*, Zhu S*, Yang L, Cui S, Pan W, Jackson R, Zheng Y, Rongvaux A, Sun Q, Yang G, Gao S, Lin R, You F, Flavell R#, Fikrig E#. Nlrp6 regulates intestinal antiviral innate immunity. Science. 2015 Nov 13;350(6262):826-30. doi: 10.1126/science.aab3145. (IF=41)
Comment in:
Science Signaling (2015) DOI: 10.1126/scisignal.aad8628; Nlrp6 keeps gut infections in check
20. Pan W*, Zhu S*, Dai D, Liu Z, Li D, Li B, Gagliani N, Zheng Y,.. Qian Y, Chen Y, Fang J, Herbst R, Richman L, Jallal B, Harley J, Flavell R, Yao Y# and Shen N#. 2015. MiR-125a targets effector programs to stabilize Treg mediated immune homeostasis and controls autoimmunity. Nature Communications. DOI: 10.1038/ncomms8096. (*co-first author) (IF=12)
19. Song X, Dai D, He X, Zhu S, Yao Y, Gao H, Wang J, Qu F, Qiu J, Wang H, Li X, Shen N, Qian Y#. 2015. Growth Factor FGF2 Cooperates with Interleukin-17 to Repair Intestinal Epithelial Damage. Immunity. doi:10.1016/j.immuni.2015.06.024. (IF=24)
18. W Pan, S Zhu, D Dai, J Harley, N Shen#. 2015. T cell transfer Model of Colitis. Bio-protocol. 10.21769/BioProtoc.1862
2014
17. Zhu S, Li HB, Flavell RA#. 2014. Resemble and Inhibit: when RLR meets TGF-b. Molecular Cell. Dec 18;56(6):719-20. doi:10.1016/j.molcel.2014.12.010. (IF=14)
16. Zhu S, Jackson R, Flavell RA#. 2014. The lock-washer: a reconciliation of the RIG-I activation models. Cell Research.10.1038/cr.2014.5. (IF=15)
15. Marcel R. de Zoete*, Noah W. Palm*, Shu Zhu*, Richard A. Flavell#. 2014. Inflammasomes. Cold Spring Haber Perspectives in Biology. Oct 16;6(12):a016287. doi: 10.1101/cshperspect.a016287 (*co-first author) (IF=12)
14. Song X, Gao H, Lin Y, Yao Y, Zhu S, Wang J, Liu Y, Yao X, Meng G, Shen N, Shi Y, Iwakura Y, Qian Y#. 2014. Alterations in the Microbiota Drive Interleukin-17C Production from Intestinal Epithelial Cells to Promote Tumorigenesis. Immunity. 40 (1), 140-152. (IF=24)
13. W Pan, S Zhu, D Dai, J Harley, N Shen#. 2014. Mir-125a Is Critical Regulator for Controlling Autoimmunity in Multiple Autoimmune Diseases through Stabilizing Treg Mediated Immune Homeostasis.Arthritis & Rheumatology.66():S1245, OCT 2014. (IF=8)
2013
12. Zhu S#, Pan W, Qian Y#. 2013. MicroRNA in immunity and autoimmunity. J Mol Med. Sep;91(9):1039-50. doi: 10.1007/s00109-013-1043-z. (#co-corresponding author; Invited review) (IF=5)
11. Cao J, Zhu S, Zhou W, Li J, Liu C, Xuan H, Yan J, Zheng L, Zhou L, Yu J, Chen G, Huang Y, Yu Z, Feng L#. 2013. PLZF Mediates the PTEN/AKT/FOXO3a Signaling in Suppression of Prostate Tumorigenesis. PLoS One. 8 (12), e77922. (IF=4)
2012
10. Zhu, S.*, W. Pan*, X. Song, Y. Liu, Y. Tang, H. Wang, W. Liu, Y. Shi, D. He, J.B. Harley, N. Shen and Y. Qian#. 2012. The microRNA miR-23b suppresses IL-17-associated autoimmune inflammation by targeting TAB2, TAB3 and IKK-α. Nature Medicine. 18: 1077-1086. DOI 10.1038/nm.2815. (IF=33)
Comment in:
Nature Medicine (2012) 18, 1009–1010; MiR-23b is a safeguard against autoimmunity.
9. Zhu, S. & Qian, Y#. 2012. IL-17/IL-17 receptor system in autoimmune disease: mechanisms and therapeutic potential. Clin Sci (Lond) 122, 487-511. (Invited review) (IF=5)
8. Yao Y., Y. Wang, F. Chen, Y. Huang, S. Zhu, Q. Leng, H. Wang, Y. Shi, Y. Qian#. 2012. NLRC5 regulates MHC class I antigen presentation in host defense against intracellular pathogen. Cell Research. 04/2012; (IF=15)
7. Qu F, Gao H, Zhu S, Shi P, Zhang Y, Liu Y, Jallal B, Yao Y, Shi Y, Qian Y#. 2012. TRAF6-Dependent Act1 Phosphorylation by the I kappa B Kinase-Related Kinases Suppresses Interleukin-17-Induced NF-kappa B Activation. Mol Cell Biol 32: 3925-3937. (IF=4)
2011
6. Song, X., S. Zhu, P. Shi, Y. Liu, Y. Shi, S.D. Levin, and Y. Qian#. 2011. IL-17RE is the functional receptor for IL-17C and mediates mucosal immunity to infection with intestinal pathogens. Nature Immunology. 12:1151-8. (IF=22)
5. Shi, P., S. Zhu, Y. Lin, Y. Liu, Z. Chen, Y. Shi, and Y. Qian#. 2011. Persistent stimulation with interleukin-17 desensitizes cells through SCFbeta-TrCP-mediated degradation of Act1. Science Signaling. 4:ra73. (IF=7)
4. Shi P, Zhu S and Y Qian#. 2011. IL-17 mediated signaling and function. Chin J Cell Bio. 2011, 33(4): 345-357. (Invited review)
2010
3. Zhu, S., W. Pan, P. Shi, H. Gao, F. Zhao, X. Song, Y. Liu, L. Zhao, X. Li, Y. Shi, and Y. Qian#. 2010. Modulation of experimental autoimmune encephalomyelitis through TRAF3-mediated suppression of interleukin 17 receptor signaling. J Exp Med. 207:2647-2662. (IF=15)
Research highlight in:
Nature Medicine (2011) 17:52; Immunology: Taming IL-17 inflammation
Nature Immunology (2011) 12:19; TRAF3 suppresses IL-17R
2. Pan, W*, S. Zhu*, M. Yuan, H. Cui, L. Wang, X. Luo, J. Li, H. Zhou, Y. Tang, and N. Shen#. 2010. MicroRNA-21 and microRNA-148a contribute to DNA hypomethylation in lupus CD4+ T cells by directly and indirectly targeting DNA methyltransferase 1. J Immunol. 184:6773-6781. (*co-first author; 331 citations) (IF=5)
2009
1. Yu, Z., P. Ji, J. Cao, S. Zhu, Y. Li, L. Zheng, X. Chen, and L. Feng#. 2009. Dazl promotes germ cell differentiation from embryonic stem cells. J Mol Cell Biol. 1:93-103. (IF=6)
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