Xiaoyuan SongPh.D. 

Professor, School of Life Sciences

University of Science & Technology of China

443 Huangshan Street, Hefei, Anhui 230027, P.R.China

Tel: 86-551-63607752 (Office) 15755126230 (Cell)

E-mail: songxy5@ustc.tsg211.com

Researcher ID: P-1094-2014

Education

1992.09-1996.06Biology, Beijing Normal University, China, B.S.

1996.09-1999.01Molecular Cell Biology, Beijing Normal University, China, M.S.Mentor: Dr. Wang, Yongchao

1999.09-2006.06Cell, Molecular and Developmental Biology, University of Rochester, USA, Ph.D.Mentor: Dr. Martin A. Gorovsky

Working Experience

1996.09-1999.01Department of Biology, Beijing Normal University, China,Research Assistant

1999.02-1999.08    Beijing Infectious Diseases Hospital, Dr. Fusheng Wang Group, Research Assistant

1999.09-2006.06Department of Biology, University of Rochester, US,Research Assistant

2006.09-2012.12    School of Medicine, University of California at San Diego, US, Postdoctoral fellowMentor: Dr. Michael G. Rosenfeld

2012.12-Present    School of Life Sciences, University of Science & Technology of China, Professor

Research Interests

1. Roles of three-dimensional transcriptional regulation of lncRNAs and 3D genome structure in brain aging.

2. Transcriptional regulation of lncRNAs and higher order chromatin structures in spermatogenesis.

Teaching Experience

2015.09-2018.12    Molecular Biology II (Graduate student course), Lecturer, 120 hours, 353 students

2016.09-2020.01Principles of Neurobiology I (Graduate students course), 104 hours, 230 students

2017.03-PresentMolecular Biology II (Undergraduate student course), Lecturer, 80 hours, 219 student

2021.03-PresentBiochemistry and Molecular Biology References reading and analysis (Graduate student course), 80hours, 52 students

Selected Publications (^#Co-first author, ^%Co-second author, ^*Corresponding author)

1. Mamun MMA, Khan MR, Zhu Y, Zhang Y, Zhou S, Xu R, Bukhari I, Thorne RF, Li J, Zhang XD, Liu G^*, Chen S^*, Wu M^*, Song X^*. Stub1 maintains proteostasis of master transcription factors in embryonic stem cells. Cell Reports 2022 Jun 7; 39(10):110919. (IF 9.423)

2. Luo Z.^#, Zhang R.^#, Hu T.^#, Zhu Y., Wu Y., Li W., Zhang Z., Yao X., Liang H., Song X.^*. NicE-C efficiently reveals open chromatin-associated chromosome interactions at high resolution. Genome Research 2022, 32(3):534-544. (IF 9.043)

3. Wang F.^#, Wang Q.^#, Liu B.^#, Mei L., Ma S., Wang S., Wang R., Zhang Y., Niu C., Xiong Z., Zheng Y., Zhang Z., Shi J., Song X.^*. The long noncoding RNA Synage regulates synapse stability and neuronal function in the cerebellum. Cell Death & Differentiation. 2021, 28(9):2634-2650. (IF 15.828)

4. Cheng Q., Wu Y, Xia H.^*, Song X.^*. RGL2 as an age-dependent factor regulates colon cancer progression. Computational and Structural Biotechnology Journal. 2021, 19: 2190-2201. (IF 7.271) 

5. Luo Z.^#, Hu T.^#, Jiang H., Wang R., Xu Q., Zhang S., Cao J., Song X.^*. Rearrangement of macronucleus chromosomes correspond to TAD-like structures of micronucleus chromosomes in Tetrahymena thermophila. Genome Research. 2020, 30(3): 406-414. (IF 9.043)

6. Luo Z.^#, Wang X.^#, Jiang H.^#, Wang R.^#, Chen J., Chen Y., Xu Q., Cao J., Gong X., Wu J., Yang Y., Li W., Han C., Cheng YC., Rosenfeld MG., Sun F.^*, Song X.^*. Reorganized 3D genome structures support transcriptional regulation in mouse spermatogenesis. iScience. 2020, 23(4): 101034. (IF 5.458)

7. Wang F.^#, Ren D.^#, Liang X.^#, Ke S., Zhang B., Hu B.^*, Song X.^*, Wang X.^*. A long noncoding RNA cluster-based genomic locus maintains proper development and visual function. Nucleic Acids Research. 2019, 47(12): 6315-6329. (IF 16.971)

8. Cao J., Jiang H.^%, Zhang R.^%, Ghanam AR.^%, Xia H., Zhu Y., Yang Z., Song X.^*. Epigenomic profiling identifies the role of Nr5a2 and CYP1B1 in hepatocellular carcinoma stemness maintenance. Science Bulletin. 2019, 64: 1132-1135. (IF 11.78)

9. Ghanam AR., Cao J., Ouyang X., and Song X.^*. New insights into chronological mobility of retrotransposable elements in vivo. Oxidative Medicine and Cellular Longevity. 2019, 2818415. eCollection 2019. （IF 6.543）

10. Xu Q.^#, Wang R.^#, Ghanam AR., Yan G., Miao W., Song X.^*. The key role of CYC2 during meiosis in Tetrahymena thermophila. Protein & Cell. 2016, 7(4):236-49. (IF 14.87 )

11. Cao J., Luo Z., Cheng Q., Xu Q., Zhang Y., Wang F., Wu Y., Song X.^*. Three-dimensional regulation of transcription. Protein & Cell. 2015, 6(4):241-53. (IF 14.87)

12. Song X., Bowen J., Miao W., Liu Y., and Gorovsky MA.^*. The nonhistone, N-terminal tail of an essential, chimeric H2A variant regulates mitotic H3-S10 dephosphorylation. Genes & Development. 2012, 26(6):615-29. (IF 11.361)

13. Song X.^#, Wang X.^#, Arai S. and Kurokawa R.^*. Promoter-associated noncoding RNA from the CCND1 promoter. Methods in Molecular Biology. 2012, 809:609-22. 

14. Harismendy O.^#, Notani D.^#, Song X., Rahim NG., Tanasa B., Heintzman N., Ren B., Fu XD., Topol EJ., Rosenfeld MG.^*, and Frazer KA.^*. 9p21 DNA variants associated with coronary artery disease impair interferon-γ signalling response. Nature. 2011, 470(7333):264-8. (IF 49.962)  

15. Wang X.^# and Song X.^#, Glass CK., and Rosenfeld MG.^*. The Long Arm of Long Noncoding RNAs: Roles as Sensors Regulating Gene Transcriptional Programs. Cold Spring Harb Perspect Biol. 2011, 3(1):a003756. Collected in《RNA Worlds》IV. (IF 10.005)

16. Wang X., Arai S.^%, Song X.^%, Reichart D., Du K., Pascual G., Tempst P., Rosenfeld MG.^*, Glass CK.^*, and Kurokawa R.^*. Induced ncRNAs allosterically modify RNA binding proteins in cis to inhibit transcription. Nature. 2008, 454(7200):126-30. (IF 49.962)

17. Song, X.^#, Gjoneska E.^#, Ren Q.^#, Taverna SD., Allis CD., and Gorovsky MA.^*. Phosphorylation of the SQ H2A.X motif is required for proper meiosis and mitosis in Tetrahymena thermophila. Mol Cell Biol. 2007, 27(7):2648-60. (IF 4.272)

18. Song X. and Gorovsky MA.^*. Unphosphorylated H1 is enriched in a specific region of the promoter when CDC2 is down-regulated during starvation. Mol Cell Biol. 2007, 27(5):1925-33. (IF 4.272)

19. Dou Y.^#, Song X.^#, Liu Y., and Gorovsky MA.^*. The H1 phosphorylation state regulates expression of CDC2 and other genes in response to starvation in Tetrahymena thermophila. Mol Cell Biol. 2005, 25(10):3914-22. (IF 4.272)

20. Shang Y., Song X., Bowen J., Corstanje R., Gao Y., Gaertig J., and Gorovsky MA.^*. A robust inducible-repressible promoter greatly facilitates gene knockouts, conditional expression, and overexpression of homologous and heterologous genes in Tetrahymena thermophila. PNAS. 2002, 99(6):3734-9. (IF 11.205)