WEI Haiming　  

12/2015–present: Professor & Vice-Dean of School of Life Sciences,,UnivSci Tech China

12/2005–12/2015: Professor, UnivSci Tech China

09/2001-11/2005: Associate Professor, UnivSci Tech China

07/1996-08/2001: Assist/Asso Professor, Shandong Acad Med Sci

08/2000-06/2003: M.D., Immunology, Shandong Univ.

08/1993-06/1996: M.S., Immunology, Shandong Acad Med Sci

Research Interests

The research in our laboratory focuses on three main topics. 1) The development and transcription regulation of human NK cells. 2) The relationship between human NK subsets and major diseases. We are interested in understanding the mechanisms of hepatitis, Immune escape by Hepatitis B Viruses and the development of auto-immune diseases. 3) Biological Treatment Technology of tumors based on innate immunity. We are currently evaluating the anti-tumor immunochemotherapy of IL-12 based on “pre-existing immunity”. We are also focusing to research and produce the anti-tumor medicine of IL-12.

Selected Publications

1. Zheng X, Fan X, Fu B, Zheng M, Zhang A, Zhong K, Yan J, Sun R, Tian Z, Wei H. EpCAM inhibition sensitizes chemoresistant leukemia to immune surveillance.Cancer Res. 2016 Oct 3. pii: canres.0842

2. Zheng X, Cheng M, Fu B, Fan X, Wang Q, Yu X, Sun R, Tian Z, Wei H. Targeting LUNX inhibits non-small cell lung cancer growth and metastasis. Cancer Res. 2015 Mar 15;75(6):1080-90

3. Lv S, Wang J, Dou S, Yang X, Ni X, Sun R, Tian Z, Wei H. Nanoparticles encapsulating HBV-CpG induce therapeutic immunity against hepatitis B virus infection. Hepatology. 2014Feb 59(2):385-94

4. Ni F, Sun R, Fu B, Wang F, Guo C, Tian Z, Wei H. IGF-1 promotes the development and cytotoxic activity of human NK cells. Nat Commun. 2013 Feb 12; 4:1479.

5. Fu B, Li X, Sun R, Tong X, Ling B, Tian Z, Wei H. Natural killer cells promote immune tolerance by regulating inflammatory TH17 cells at the human maternal-fetal interface. Proc Natl AcadSci U S A. 2013 Jan 15;110(3):E231-40.

6. Li F, Wei H, Wei H, Gao Y, Xu L, Yin W, Sun R, Tian Z. Blocking the Natural Killer Cell Inhibitory Receptor NKG2A Increases Activity of Human Natural Killer Cells and Clears Hepatitis B Virus Infection in Mice. Gastroenterology. 2013 Feb;144(2):392-401

7. Sun C, Fu B, Gao Y, Liao X, Sun R, Tian Z, Wei H. TGF-β1 down-regulation of NKG2D/DAP10 and 2B4/SAP expression on human NK cells contributes to HBV persistence. PLoSPathog. 2012;8(3):e1002594